Genomes and Pathogenicity

Burkholderia cepacia complex (Bcc) are the most common objectionable microorganisms contaminating pharmaceutical and personal care products (PPCPs). A species of B. cepacia complex called B. contaminans, is often found in PPCPs. We have produced a draft genome sequence of an isolate recovered from PPCP in collaboration with Dr. Jose Degrossi. Read more about sequencing of Bcc genomes here.

We are also using whole genome sequencing and bioinformatics to understand evolutionary mechanisms that allow the superbug Staphylococcus aureus to develop multiple resistance to antibiotics, becoming a significant health threat. In collaboration with Dr. Marta Mollerach, Dr. George Golding, Dr. Morag Graham and Dr. Gary VanDomselaar, we are sequencing and comparing the genomes of community-acquired and sequential cystic fibrosis isolates by detecting single nucleotide polymorphisms, insertion/deletions and other genomic structural variations.